Development and validation of a custom made indocyanine green fluorescence lymphatic vessel imager.
Identifieur interne : 001F09 ( Main/Exploration ); précédent : 001F08; suivant : 001F10Development and validation of a custom made indocyanine green fluorescence lymphatic vessel imager.
Auteurs : Olivia J. Pallotta [Australie] ; Malou Van Zanten [Australie] ; Mark Mcewen [Australie] ; Lynne Burrow [Australie] ; Jack Beesley [Australie] ; Neil Piller [Australie]Source :
- Journal of biomedical optics [ 1560-2281 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Colorants fluorescents (), Colorants fluorescents (administration et posologie), Colorants fluorescents (usage thérapeutique), Conception d'appareillage, Femelle, Humains, Imagerie optique (), Imagerie optique (instrumentation), Lymphoedème (), Lymphoedème (anatomopathologie), Mâle, Reproductibilité des résultats, Suidae, Sujet âgé, Traitement d'image par ordinateur, Vaisseaux lymphatiques (anatomopathologie), Vert indocyanine (), Vert indocyanine (administration et posologie), Vert indocyanine (usage thérapeutique).
- MESH :
- administration et posologie : Colorants fluorescents, Vert indocyanine.
- anatomopathologie : Lymphoedème, Vaisseaux lymphatiques.
- usage thérapeutique : Colorants fluorescents, Imagerie optique, Vert indocyanine.
- Adulte, Adulte d'âge moyen, Animaux, Colorants fluorescents, Conception d'appareillage, Femelle, Humains, Imagerie optique, Lymphoedème, Mâle, Reproductibilité des résultats, Suidae, Sujet âgé, Traitement d'image par ordinateur, Vert indocyanine.
English descriptors
- KwdEn :
- Adult, Aged, Animals, Equipment Design, Female, Fluorescent Dyes (administration & dosage), Fluorescent Dyes (chemistry), Fluorescent Dyes (therapeutic use), Humans, Image Processing, Computer-Assisted, Indocyanine Green (administration & dosage), Indocyanine Green (chemistry), Indocyanine Green (therapeutic use), Lymphatic Vessels (pathology), Lymphedema (pathology), Lymphedema (surgery), Male, Middle Aged, Optical Imaging (instrumentation), Optical Imaging (methods), Reproducibility of Results, Swine.
- MESH :
- chemical , administration & dosage : Fluorescent Dyes, Indocyanine Green.
- chemical , chemistry : Fluorescent Dyes, Indocyanine Green.
- chemical , therapeutic use : Fluorescent Dyes, Indocyanine Green.
- instrumentation : Optical Imaging.
- methods : Optical Imaging.
- pathology : Lymphatic Vessels, Lymphedema.
- surgery : Lymphedema.
- Adult, Aged, Animals, Equipment Design, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Reproducibility of Results, Swine.
Abstract
Lymphoedema is a chronic progressive condition often producing significant morbidity. An in-depth understanding of an individual's lymphatic architecture is valuable both in the understanding of underlying pathology and for targeting and tailoring treatment. Severe lower limb injuries resulting in extensive loss of soft tissue require transposition of a flap consisting of muscle and/or soft tissue to close the defect. These patients are at risk of lymphoedema and little is known about lymphatic regeneration within the flap. Indocyanine green (ICG), a water-soluble dye, has proven useful for the imaging of lymphatic vessels. When injected into superficial tissues it binds to plasma proteins in lymph. By exposing the dye to specific wavelengths of light, ICG fluoresces with near-infrared light. Skin is relatively transparent to ICG fluorescence, enabling the visualization and characterization of superficial lymphatic vessels. An ICG fluorescence lymphatic vessel imager was manufactured to excite ICG and visualize real-time fluorescence as it travels through the lymphatic vessels. Animal studies showed successful ICG excitation and detection using this imager. Clinically, the imager has assisted researchers to visualize otherwise hidden superficial lymphatic pathways in patients postflap surgery. Preliminary results suggest superficial lymphatic vessels do not redevelop in muscle flaps.
DOI: 10.1117/1.JBO.20.6.066003
PubMed: 26057032
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000E44
- to stream PubMed, to step Curation: 000E44
- to stream PubMed, to step Checkpoint: 000E44
- to stream Ncbi, to step Merge: 007476
- to stream Ncbi, to step Curation: 007476
- to stream Ncbi, to step Checkpoint: 007476
- to stream Main, to step Merge: 001F12
- to stream Main, to step Curation: 001F09
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development and validation of a custom made indocyanine green fluorescence lymphatic vessel imager.</title><author><name sortKey="Pallotta, Olivia J" sort="Pallotta, Olivia J" uniqKey="Pallotta O" first="Olivia J" last="Pallotta">Olivia J. Pallotta</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042</wicri:regionArea><wicri:noRegion>Bedford Park SA 5042</wicri:noRegion></affiliation></author><author><name sortKey="Van Zanten, Malou" sort="Van Zanten, Malou" uniqKey="Van Zanten M" first="Malou" last="Van Zanten">Malou Van Zanten</name><affiliation wicri:level="1"><nlm:affiliation>Flinders University, Department of Surgery, Lymphoedema Research Unit, Level 3, Flinders Medical Centre, Bedford Park, SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders University, Department of Surgery, Lymphoedema Research Unit, Level 3, Flinders Medical Centre, Bedford Park, SA 5042</wicri:regionArea><wicri:noRegion>SA 5042</wicri:noRegion></affiliation></author><author><name sortKey="Mcewen, Mark" sort="Mcewen, Mark" uniqKey="Mcewen M" first="Mark" last="Mcewen">Mark Mcewen</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042</wicri:regionArea><wicri:noRegion>Bedford Park SA 5042</wicri:noRegion></affiliation></author><author><name sortKey="Burrow, Lynne" sort="Burrow, Lynne" uniqKey="Burrow L" first="Lynne" last="Burrow">Lynne Burrow</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042</wicri:regionArea><wicri:noRegion>Bedford Park SA 5042</wicri:noRegion></affiliation></author><author><name sortKey="Beesley, Jack" sort="Beesley, Jack" uniqKey="Beesley J" first="Jack" last="Beesley">Jack Beesley</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042</wicri:regionArea><wicri:noRegion>Bedford Park SA 5042</wicri:noRegion></affiliation></author><author><name sortKey="Piller, Neil" sort="Piller, Neil" uniqKey="Piller N" first="Neil" last="Piller">Neil Piller</name><affiliation wicri:level="1"><nlm:affiliation>Flinders University, Department of Surgery, Lymphoedema Research Unit, Level 3, Flinders Medical Centre, Bedford Park, SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders University, Department of Surgery, Lymphoedema Research Unit, Level 3, Flinders Medical Centre, Bedford Park, SA 5042</wicri:regionArea><wicri:noRegion>SA 5042</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26057032</idno><idno type="pmid">26057032</idno><idno type="doi">10.1117/1.JBO.20.6.066003</idno><idno type="wicri:Area/PubMed/Corpus">000E44</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E44</idno><idno type="wicri:Area/PubMed/Curation">000E44</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E44</idno><idno type="wicri:Area/PubMed/Checkpoint">000E44</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E44</idno><idno type="wicri:Area/Ncbi/Merge">007476</idno><idno type="wicri:Area/Ncbi/Curation">007476</idno><idno type="wicri:Area/Ncbi/Checkpoint">007476</idno><idno type="wicri:Area/Main/Merge">001F12</idno><idno type="wicri:Area/Main/Curation">001F09</idno><idno type="wicri:Area/Main/Exploration">001F09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Development and validation of a custom made indocyanine green fluorescence lymphatic vessel imager.</title><author><name sortKey="Pallotta, Olivia J" sort="Pallotta, Olivia J" uniqKey="Pallotta O" first="Olivia J" last="Pallotta">Olivia J. Pallotta</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042</wicri:regionArea><wicri:noRegion>Bedford Park SA 5042</wicri:noRegion></affiliation></author><author><name sortKey="Van Zanten, Malou" sort="Van Zanten, Malou" uniqKey="Van Zanten M" first="Malou" last="Van Zanten">Malou Van Zanten</name><affiliation wicri:level="1"><nlm:affiliation>Flinders University, Department of Surgery, Lymphoedema Research Unit, Level 3, Flinders Medical Centre, Bedford Park, SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders University, Department of Surgery, Lymphoedema Research Unit, Level 3, Flinders Medical Centre, Bedford Park, SA 5042</wicri:regionArea><wicri:noRegion>SA 5042</wicri:noRegion></affiliation></author><author><name sortKey="Mcewen, Mark" sort="Mcewen, Mark" uniqKey="Mcewen M" first="Mark" last="Mcewen">Mark Mcewen</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042</wicri:regionArea><wicri:noRegion>Bedford Park SA 5042</wicri:noRegion></affiliation></author><author><name sortKey="Burrow, Lynne" sort="Burrow, Lynne" uniqKey="Burrow L" first="Lynne" last="Burrow">Lynne Burrow</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042</wicri:regionArea><wicri:noRegion>Bedford Park SA 5042</wicri:noRegion></affiliation></author><author><name sortKey="Beesley, Jack" sort="Beesley, Jack" uniqKey="Beesley J" first="Jack" last="Beesley">Jack Beesley</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Biomedical Engineering at Flinders Medical Centre, Flinders Biomedical Engineering Department, Research & Teaching, Bedford Park SA 5042</wicri:regionArea><wicri:noRegion>Bedford Park SA 5042</wicri:noRegion></affiliation></author><author><name sortKey="Piller, Neil" sort="Piller, Neil" uniqKey="Piller N" first="Neil" last="Piller">Neil Piller</name><affiliation wicri:level="1"><nlm:affiliation>Flinders University, Department of Surgery, Lymphoedema Research Unit, Level 3, Flinders Medical Centre, Bedford Park, SA 5042, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders University, Department of Surgery, Lymphoedema Research Unit, Level 3, Flinders Medical Centre, Bedford Park, SA 5042</wicri:regionArea><wicri:noRegion>SA 5042</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of biomedical optics</title><idno type="eISSN">1560-2281</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Animals</term><term>Equipment Design</term><term>Female</term><term>Fluorescent Dyes (administration & dosage)</term><term>Fluorescent Dyes (chemistry)</term><term>Fluorescent Dyes (therapeutic use)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Indocyanine Green (administration & dosage)</term><term>Indocyanine Green (chemistry)</term><term>Indocyanine Green (therapeutic use)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphedema (pathology)</term><term>Lymphedema (surgery)</term><term>Male</term><term>Middle Aged</term><term>Optical Imaging (instrumentation)</term><term>Optical Imaging (methods)</term><term>Reproducibility of Results</term><term>Swine</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Colorants fluorescents ()</term><term>Colorants fluorescents (administration et posologie)</term><term>Colorants fluorescents (usage thérapeutique)</term><term>Conception d'appareillage</term><term>Femelle</term><term>Humains</term><term>Imagerie optique ()</term><term>Imagerie optique (instrumentation)</term><term>Lymphoedème ()</term><term>Lymphoedème (anatomopathologie)</term><term>Mâle</term><term>Reproductibilité des résultats</term><term>Suidae</term><term>Sujet âgé</term><term>Traitement d'image par ordinateur</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vert indocyanine ()</term><term>Vert indocyanine (administration et posologie)</term><term>Vert indocyanine (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Fluorescent Dyes</term><term>Indocyanine Green</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fluorescent Dyes</term><term>Indocyanine Green</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Fluorescent Dyes</term><term>Indocyanine Green</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Colorants fluorescents</term><term>Vert indocyanine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Optical Imaging</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Optical Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Colorants fluorescents</term><term>Imagerie optique</term><term>Vert indocyanine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Animals</term><term>Equipment Design</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Reproducibility of Results</term><term>Swine</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Colorants fluorescents</term><term>Conception d'appareillage</term><term>Femelle</term><term>Humains</term><term>Imagerie optique</term><term>Lymphoedème</term><term>Mâle</term><term>Reproductibilité des résultats</term><term>Suidae</term><term>Sujet âgé</term><term>Traitement d'image par ordinateur</term><term>Vert indocyanine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphoedema is a chronic progressive condition often producing significant morbidity. An in-depth understanding of an individual's lymphatic architecture is valuable both in the understanding of underlying pathology and for targeting and tailoring treatment. Severe lower limb injuries resulting in extensive loss of soft tissue require transposition of a flap consisting of muscle and/or soft tissue to close the defect. These patients are at risk of lymphoedema and little is known about lymphatic regeneration within the flap. Indocyanine green (ICG), a water-soluble dye, has proven useful for the imaging of lymphatic vessels. When injected into superficial tissues it binds to plasma proteins in lymph. By exposing the dye to specific wavelengths of light, ICG fluoresces with near-infrared light. Skin is relatively transparent to ICG fluorescence, enabling the visualization and characterization of superficial lymphatic vessels. An ICG fluorescence lymphatic vessel imager was manufactured to excite ICG and visualize real-time fluorescence as it travels through the lymphatic vessels. Animal studies showed successful ICG excitation and detection using this imager. Clinically, the imager has assisted researchers to visualize otherwise hidden superficial lymphatic pathways in patients postflap surgery. Preliminary results suggest superficial lymphatic vessels do not redevelop in muscle flaps.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Pallotta, Olivia J" sort="Pallotta, Olivia J" uniqKey="Pallotta O" first="Olivia J" last="Pallotta">Olivia J. Pallotta</name></noRegion><name sortKey="Beesley, Jack" sort="Beesley, Jack" uniqKey="Beesley J" first="Jack" last="Beesley">Jack Beesley</name><name sortKey="Burrow, Lynne" sort="Burrow, Lynne" uniqKey="Burrow L" first="Lynne" last="Burrow">Lynne Burrow</name><name sortKey="Mcewen, Mark" sort="Mcewen, Mark" uniqKey="Mcewen M" first="Mark" last="Mcewen">Mark Mcewen</name><name sortKey="Piller, Neil" sort="Piller, Neil" uniqKey="Piller N" first="Neil" last="Piller">Neil Piller</name><name sortKey="Van Zanten, Malou" sort="Van Zanten, Malou" uniqKey="Van Zanten M" first="Malou" last="Van Zanten">Malou Van Zanten</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F09 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F09 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:26057032
|texte= Development and validation of a custom made indocyanine green fluorescence lymphatic vessel imager.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26057032" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |